Cancer and Precision Medicine
Cancer is a complicated disease caused by genetic variation. The genetic variation may deprive cells of the normal control function, leading to immortalization and cancer. And targeted drugs work well in cancer therapy, which can kill cancer cells that carry specific genes of variation. However, patients may differ from each other regarding the in vivo genetic variation. As a result, patients vary in the susceptibility and toxic and side effects to the same anti-cancer drugs. As the more inclusive “molecular typing” is proposed, more patients are able to accept targeted therapy, where physicians can custom therapeutic regimens for cancer patients varying in genetic variation to tap as many potentially available targeted drugs as possible and enhance therapeutic efficiency of the drugs. That’s how precision medicine works. Precision medicine needs a prerequisite - precision diagnosis.
Solid tumor patients
Solid tumor patients whose tissue is not available
- 1. Patients with ovarian cancer, prostate cance, pancreatic cancer, breast cancer, bladder cancer and other diseases that may have homologous recombination repair defect (HRD) related gene mutations.
- 2. Patients who need to assess the efficacy and estimated outcome of chemotherapy and targeted therapy by analyzing the complete HRD status.
- 3. Patients who need to understand family risks.